MP29-10 INCREASED PREVALENCE OF URINARY TRACT INFECTIONS AND CATHETER-ASSOCIATED URINARY TRACT INFECTIONS IN DISORDERS CHARACTERIZED BY IRON DYSREGULATION

You have accessJournal of UrologyInfections/Inflammation/Cystic Disease the Genitourinary Tract: Kidney & Bladder II (MP29)1 Sep 2021MP29-10 INCREASED PREVALENCE OF URINARY TRACT INFECTIONS AND CATHETER-ASSOCIATED IN DISORDERS CHARACTERIZED BY IRON DYSREGULATION Barbara Prol, Arrie Selva, Pamela Patton, Zhaoyi Chen, and Victoria Bird ProlBarbara Prol More articles by this author , SelvaArrie Selva PattonPamela Patton ChenZhaoyi Chen BirdVictoria View All Author Informationhttps://doi.org/10.1097/JU.0000000000002026.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION OBJECTIVE: Urinary tract infection (UTI) accounts for up 40% all healthcare-associated infections its prevalence varies among different populations. Bacteria require iron-rich environments optimal survival. Escherichia coli (E. coli), most common pathogen responsible UTI, has been shown thrive in environments. Our aim was explore UTI catheter-associated urinary (CAUTI) a cohort patients with iron-sequestering disorders compared other METHODS: The University Florida Health Informatics Integrating Biology Bedside (i2b2) system queried purpose retrospective analysis CAUTI associated E. sepsis. International Classification Codes (ICD-9 ICD-10) were used obtain our target diagnoses interest, subjects classically iron-wasting diseases: sickle cell anemia (SS), thalassemia (T), hemochromatosis (H). Control groups included general population (GP) Crohn’s disease (CD) ulcerative colitis (UC). Univariate performed. We SASv.9.4 analysis. P-values calculated comparison GP. RESULTS: A total 1.1 million from 2012-2018 data query. GP, CD UC 4.8%, 12.8% 12.5%, respectively (p <0.0001 UC). CD, 0.1%, 0.4%, 0.6%, In comparison, SS, T, H 21.1%, 14.8% 14.9%, H). SS 0.9 0.7%, sepsis H, UC, 1.3%, 0.3%, respectively, 0.05% GP <0.0004 T; p CD). CONCLUSIONS: Both iron-deficient significantly higher when particular, suggest that individuals represent vulnerable group susceptible all: CAUTI, urosepsis, coli-related septicemia. Iron imbalance is novel risk factor development related infections. Efforts aimed at prevention should be pursued these high-risk further research directed towards phenomenon. Source Funding: none © 2021 American Urological Association Education Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e493-e493 Advertisement Copyright Permissions© Inc.MetricsAuthor Information Expand Loading ...